Endocrine Abstracts

Aims: A critical function of astrocytes is to recycle glutamate to neurons as glutamine to sustain glutamatergic neurotransmission. In the hypothalamus, this is required for effective counterregulatory hormone release in response to hypoglycaemia. However, after recurrent hypoglycaemia in vivo, this is attenuated. The aim of this study was to characterise how rat primary hypothalamic and cortical astrocytes adapt to recurrent low glucose (RLG) with repeated exposure t...